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There is an increased expression of iNOS in the airways of asthmatic individuals, particularly in epithelial and inflammatory cells, including macrophages, neutrophils, and eosinophils

The protein has been shown to protect mice from LPS-induced inflammation and, when mixed with LPS, significantly reduces TNF and IL-1 levels in circulation

Tolerability (human reports): Small uncontrolled reports describe NAD+ infusions as generally tolerated, with dose-related flushing and GI effects

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